Abstract
Cycas pectinata Buch.-Ham. is commonly used in folk medicine against various disorders. The present study investigated the antidepressant and cytotoxicity activity of methanol extract of C. pectinata (MECP) along with quantitative phytochemical analysis by GC-MS method. Here, the GC-MS study of MECP presented 41 compounds, among which most were fatty acids, esters, terpenoids and oximes. The antidepressant activity was assessed by the forced swimming test (FST) and tail suspension test (TST) models. In contrast, MECP (200 and 400 mg/kg) exhibited a significant and dose-dependent manner reduction in immobility comparable with fluoxetine (10 mg/kg) and phenelzine (20 mg/kg). MECP showed a weak toxicity level in the brine shrimp lethality bioassay (ED50: 358.65 µg/mL) comparable to the standard drug vincristine sulfate (ED50: 2.39 µg/mL). Three compounds from the GC-MS study were subjected to density functional theory (DFT) calculations, where only cyclopentadecanone oxime showed positive and negative active binding sites. Cyclopentadecanone oxime also showed a good binding interaction in suppressing depression disorders by blocking monoamine oxidase and serotonin receptors with better pharmacokinetic and toxicological properties. Overall, the MECP exhibited a significant antidepressant activity with moderate toxicity, which required further advance studies to identify the mechanism.
Highlights
Depression is a condition characterized by a lowering of the mood and dislike for movement that may distress an individual’s thoughts, conduct, emotions, and comfort [1]
Depressive behavior is the feature of some psychiatric disorders, which may be caused by somewhat normal life situations; for example, deprivation of sleep, sicknesses, or an adverse effect of drugs and clinical treatments
In the present study we report the antidepressant activity along with the cytotoxicity activity of C. pectinate to find a potential lead compound from C. pectinata in alleviating depression disorders by blocking monoamine oxidase (MAOs) and serotonin receptors
Summary
Depression is a condition characterized by a lowering of the mood and dislike for movement that may distress an individual’s thoughts, conduct, emotions, and comfort [1]. Depressive behavior is connected with suicide, which ranges from 10 and 20 million each year [2,3]. The physical changes happen in extreme, vital, or melancholia or melancholic depression. These comprise sleep deprivation or hypersomnia, modified eating disorders, anorexia and weight reduction and several endocrine dysfunctions with alterations in body temperature. Depressive behavior is the feature of some psychiatric disorders, which may be caused by somewhat normal life situations; for example, deprivation of sleep, sicknesses, or an adverse effect of drugs and clinical treatments. Patients with major depressive behavior have several symptoms that may reflect in the brain, monoamine synapses or neurotransmitters, explicitly norepinephrine, serotonin, and dopamine [5,6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
