Abstract
Vetiver (Vetiveria zizanioides) essential oil (VEO) has a long history of use. However, research on its biological activity in human skin cells is scarce. In this study, we investigated the biologi...
Highlights
Vetiver essential oil (VEO) is produced by steam distillation of the aromatic roots of the tropical grass Vetiveria zizanioides, which is native to the Indian subcontinent
Bioactivity profile of VEO in pre-inflamed human dermal fibroblasts We analyzed the activity of VEO in a dermal fibroblast system, HDF3CGF, which features the microenvironment of inflamed human skin cells with boosted inflammatory and immune responses
VEO significantly inhibited the production of collagen III, an extracellular matrix protein and fibrillar collagen found extensively in connective tissues that is critically involved in the tissue remodeling process
Summary
Vetiver essential oil (VEO) is produced by steam distillation of the aromatic roots of the tropical grass Vetiveria zizanioides, which is native to the Indian subcontinent. VEO has a long history of use primarily due to its insect-repellent property and persistent green-woody note. Scientific studies have evaluated its insect-repellent, anti-inflammatory, antioxidant, and metabolic activities in several settings (Chou, Lai, Lin, & Shih, 2012; Nararak et al, 2016). Anxiolytic and refreshing effects of VEO aromatherapy have been demonstrated in rats (Cheaha et al, 2016; Saiyudthong, Pongmayteegul, Marsden, & Phansuwan-Pujito, 2015). VEO has become increasingly popular in products for topical use as well as aromatherapy. Research on the biological activity of VEO in a human skin model is scarce
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