Abstract
Gold nanoparticles are of great interest to the scientific community owing to their potential applications in biology and medicine, earned by their extraordinary optical and chemical properties; counting their excellent biocompatibility, colloidal stability and suitable surface properties for conjugation with biomaterials. In this study, GABA, a classic neurotransmitter was conjugated with gold nanoparticles (Au@GABA). The gold nanoconjugates were synthesized by forming a covalent bond between gold nanoparticles and GABA. Au@GABA nanoconjugates showed excellent optical features and superior stability under physiological conditions. Results from UV-Vis, FTIR and Raman spectroscopies proved the optimum optical properties and chemical composition of the nanoconjugates. The surface charge was characterized by gel electrophoresis and the morphological properties by scanning electron microscopy. Bare gold nanoparticles and nanoconjugates were tested by electrophysiological recording in oocytes of Xenopus laevis expressing GABA rho 1 receptor.
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