Abstract
The concentration of mouse haptoglobin in serum was increased by administration of an antitumor polysaccharide, PSK. The administration of the purified mouse haptoglobin inhibited the growth of Sarcoma-180 cells implanted in ICR mice. Furthermore, this glycoprotein enhanced macrophage activitiesin vitro, as judged from the cytostatic and cytolytic activities, glycose consumption, O2-production, and interleukin-1 production of macrophages. In addition, mouse haptoglobin enhanced the cytolytic effect of cytotoxic T-lymphocytes. These results suggested that haptoglobin has a role in restoring or enhancing the resistance of the host against tumors.
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