Abstract
Freshly prepared N2 and Riebler's paste were implanted in the mandibles of guinea pigs. Fifty-two implants of each root canal filling material were inserted. Thirteen implants of each type of paste were removed after 3 days, 1 week, 2 weeks, and 12 weeks. Histologic examination revealed extensive tissue necrosis in the form of so-called fixation intra vitam. In the cases treated with N2 the necrosis reached its maximum within 1 week; and in those treated with Riebler's paste, within 3 days. The tissue damage by N2 also persisted 2 weeks after implantation, but by 12 weeks the necrotic tissue had been largely resorbed and replaced by granulation tissue without signs of bone regeneration. The damage caused by Riebler's paste also persisted unchanged 12 weeks after implantation. N2 and Riebler's paste in contact with vital tissue produced extensive damage in the form of necrosis.
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