Abstract
BioEssaysVolume 34, Issue 1 Cover PictureFree Access BioEssays 1/2012 First published: 14 December 2011 https://doi.org/10.1002/bies.201190074AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Early eye development: Formation of the optic cup. Eye development is a complex process involving evagination and invagination processes of the retinal epithelium to form a double-walled cup structure. On pages 17–25 Eiraku et al. introduce a new model explaining the tissue dynamics that enable the spontaneous invagination of the neural retina. This “relaxation-expansion” model involves the following consecutive local rules: relaxation in the neural retina, apical constriction at the boundary epithelium between the neural retina and retinal pigment epithelium domains (hinge) and tangential expansion in the neural retina. Computer simulation of this model successfully recapitulates optic-cup morphogenesis. Cover by M. Eiraku, T. Adachi and Y. Sasai. Volume34, Issue1January 2012 RelatedInformation
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