Abstract
Self-assembly of biological molecules on solid materials is central to the “bottom-up” approach to directly integrate biology with electronics. Inspired by biology, exquisite biomolecular nanoarchitectures have been formed on solid surfaces. We demonstrate that a combinatorially-selected dodecapeptide and its variants self-assemble into peptide nanowires on two-dimensional nanosheets, single-layer graphene and MoS2. The abrupt boundaries of nanowires create electronic junctions via spatial biomolecular doping of graphene and manifest themselves as a self-assembled electronic network. Furthermore, designed peptides form nanowires on single-layer MoS2 modifying both its electric conductivity and photoluminescence. The biomolecular doping of nanosheets defined by peptide nanostructures may represent the crucial first step in integrating biology with nano-electronics towards realizing fully self-assembled bionanoelectronic devices.
Highlights
Due to its simple structure and rich electric properties[6]
Designing and controlling the peptide assembly could potentially facilitate the formation of structurally defined bio/nano interfaces as well as molecular organization on 2D materials and regulating electronic characteristics of the solid substrate
A simple mutation of the sequence induces peptides to assemble in random vs. ordered organization with significantly different resultant effects, examined by field effect transistors (FETs) of graphene and MoS2
Summary
Due to its simple structure and rich electric properties[6]. Transition metal dichalcogenides (MoS2, WSe2, etc.) are new members of 2D semiconductors with unique electronic[20,21] and optical properties[22,23,24]. Designing and controlling the peptide assembly could potentially facilitate the formation of structurally defined bio/nano interfaces as well as molecular organization on 2D materials and regulating electronic characteristics of the solid substrate. Electronic characteristics of graphene are highly sensitive to adsorbed molecules via chemical doping[25,26,27]. The doping has been investigated in single-layer MoS2 with its photoluminescence[28]. Extending this strategy, electronic characteristics of 2D single layer materials may be tuned by adsorbed peptides. Different from simple organic synthetic molecules, peptides have a wide-range of chemistry and molecular folding inherent in their amino acid content and sequence, and play a major role in cell-cell, protein-cell, and protein-DNA interactions[29]. Peptide’s interaction with a single layer material should be correlated with both its sequence and conformation on the surface
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