Abstract
SummaryBacterial infections caused by pathogens have always been a thorny issue that threatens human health, and there is urgent need to develop a new generation of antimicrobial nano-agents and treatments. Herein, biodegradable nickel disulfide (ND) nanozymes as excellent antibacterial agents that integrate excellent photothermal performance, nano-catalysis property, and glutathione (GSH)-depleting function have been successfully constructed. The ND nanozymes can effectively catalyze the decomposition of H2O2 to produce ⋅OH, and the hyperthermia of ND nanozymes generated by photothermal therapy (PTT) can further increase its catalytic activity, which provides rapid and effective bacterial killing effect compared with nano-catalytic treatment or PTT alone. Surprisingly, the ND nanozymes have the ability of GSH consumption, thus enhancing its sterilization effect. Moreover, the ND nanozymes are biodegradable nanomaterials that do not cause any significant toxicity in vivo. Collectively, the ND nanozymes with excellent photothermal performance, catalytic activity, and GSH-depleting function are used for high-efficiency sterilization.
Highlights
Bacterial infection has become a fatal worldwide health problem faced by human beings due to its high morbidity and mortality (Huo et al, 2019; Miao et al, 2019; Wang et al, 2019a; Wentao et al, 2019; Zhang et al, 2019b)
Characterization of nickel disulfide (ND) Nanozymes Monodisperse and uniform ND nanozymes were successfully prepared by a facile PVP-assisted solvothermal method (Figure 1A), and the formation mechanism could be explained by the La Mer scheme based on the previous report (Wang et al, 2020b)
The Transmission electron microscopic (TEM) image further demonstrated that the ND nanozymes had highly ordered pore structures, which was due to the spherical accumulation of NiS2 nanocrystals (Figure 1C)
Summary
Bacterial infection has become a fatal worldwide health problem faced by human beings due to its high morbidity and mortality (Huo et al, 2019; Miao et al, 2019; Wang et al, 2019a; Wentao et al, 2019; Zhang et al, 2019b). Benefiting from the rapid rise and development of nanozymes, more attention has been paid to the study of using inorganic Fenton/Fenton-like reagents with horseradish peroxidase (HRP)-mimic ability to kill bacteria (Cao et al, 2019; Sang et al, 2019; Xi et al, 2019a) These reagents have been generally considered explored as excellent reactive HRP-like nanozymes, which can effectively catalyze the typical peroxidaselike reaction in the presence of H2O2, producing lots of reactive oxygen species (ROS) that have prominent oxidation effect (e.g., ,OH) (Huo et al, 2019; Wang et al, 2020a).
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