Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon–norfloxacin intercalated layered double hydroxides

Abstract

In recent years, the development of systems with progressive drug release properties, which is an effective technique for the use of drugs, has aroused great interest in the field of controlled release formulations. In this work, hybrid materials containing citric acid cross–linked carboxymethyl cellulose (CMC) and norfloxacin (NOR) intercalated layered double hydroxide (LDH) deposited over the surface of functionalized carbon (AC) were prepared. The synthesized CMC@AC–LDHNOR nanohybrids were characterized using different techniques and in vitro NOR release behaviors were investigated in phosphate buffer saline, pH 7.4 at 37 °C. On the basis of the release profiles, it was found that NOR release was delayed when it was intercalated in AC–LDH which in presence of modified CMC decreases further. The nanohybrids indicated enhancement of antibacterial activity against gram–negative and gram–positive bacteria. The MTT assay showed their non–toxic behavior against ovarian normal epithelial and cancer cells, suggesting their potential use as drug carriers.