Abstract
To investigate the biocompatibility of the new single-needle (SN) technique of the AS 104 blood cell separator, we analysed coagulation, complement and haemolysis parameters prior to, during and after five plateletphereses. The data were compared with results of the same parameters from identical donors in the dual-needle (DN) procedure. The analysis of bilirubin, lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH) and haptoglobin showed that there was no relevant haemolysis. However, changes of the concentration of the coagulation factors XII and XI indicated an activation of coagulation. This was confirmed by an increase of the thrombin antithrombin (TAT) III complex during apheresis. Comparison of the platelet products showed no significant differences. Glucose concentration was 332 ± 14 mg/dL in the SN and 312 ± 32 mg/dL in the DN procedure, respectively. Lactate level was 3.2 ± 0.6 mmol/L in the SN and 3.3 ± 0.6 in the DN technique, respectively. Levels of complement activation markers were not statistically different. Leukocyte contamination was statistically higher in the SN procedure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
