Abstract
This study investigated the short-term subcutaneous tissue reaction and biomineralization ability of two epoxy-based root canal sealers containing calcium hydroxide (MBP and MBPc) and ProRoot MTA. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of Wistar rats (n=52) for 7 or 30days; empty implanted tubes served as controls. Specimens were stained with hematoxylin-eosin and von Kossa stain or left unstained for observation under polarized light. Qualitative and quantitative evaluations of all tissue reactions were performed. One-way anova and the Kruskal-Wallis test were used for statistical analysis (P<0.05). No significant differences were observed among the groups. All three materials induced mild-to-moderate tissue reactions at 7days, which decreased over time. Dystrophic mineralization and birefringent structures were observed only in the ProRoot MTA (®) group. Both MBP and MBPc appear to be biocompatible but do not stimulate biomineralization.
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