Abstract
Extract of green tea (GT), Proanthocyanidins (PACs) 95% (Noxy life) which classified as a “dietary supplement” under the Dietary Supplement Health and Education and combination of them has been used to help normalize hyperglycemia level and delay sugar absorption so it delayed the complication of diabetes mellitus (diabetic nephropathy).These due to their high content of the active constituents, catechins, 1– 5% xanthine alkaloids (caffeine, theobromine, theophylline, xanthine) 20–30 % flavonols; 3– 4% flavonols and flavone-glycosides; about 5% phenolic acids; 2– 3% proanthocyanidins, 0.59– 3.97% free amino acids; and minerals including significant amounts of aluminum, manganese, fluoride, and potassium.
Highlights
Diabetes mellitus is a serious metabolic disorder with micro and macro vascular complication that is defined by relative or absolute deficiency of insulin secretion
This study reveals a number of important findings on the relationship between Diabetic Nephropathy (DN), oxidant stress and the chronic consumption of green tea (GT), PACs and combination of them
The present study demonstrates that treatment of alloxan diabetic rats with dry GT leads to a significant reduction in blood glucose levels
Summary
Diabetes mellitus is a serious metabolic disorder with micro and macro vascular complication that is defined by relative or absolute deficiency of insulin secretion. Treatment of diabetic rats with green tea, PACs 95% (Noxy life) and combination of them for 6 weeks results in a decrease in blood glucose level by 128.5%, 128.5% and 71.4% respectively which reached 1.6±0.2 mg/dl p= 0.001**, 1.6±0.2 mg/dl P=0.001** and 1.2±0.3 mg/dl P=0.001** respectively (Table 3 & Figure 3). Treatment of diabetic rats with green tea, PACs 95% (Noxy life) and combination of them for 6 weeks results in a decrease in blood glucose level by 20.1%, 32.3% and 9.01% respectively which reached 29.9±4.1mg/g. E- represents a Section in kidney from animal group given PACs 95% (Noxy life) and showed cloudy swelling of renal tubules (short arrow), lobulated glomerulus with widening of meningeal space (long Arrow), few inflammatory cellular infiltrates (blue arrow) (Figure 10)
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