Abstract
Glutathione-S-transferases are an important group of detoxifying enzymes which occur in many species and catalyse the reaction of reduced glutathione (GSH) with a wide variety of eiectrophilic compounds. Starch gel electrophoresis, followed by specific staining for glutathionc-S-transferase has allowed the first genetic analysis of this group of enzymes. Our data indicate that the glutathione-S-transferases in man arc the products of at least 3 loci. In liver, 2 loci GST 1 and GST 2 are expressed strongly and have multiple alleles. The GST , locus has 2 electrophoretically distinguishable alleles, but there is strong evidence for the existence of a common null allele at that locus. Frequency of alleles at the GST 1 and GST 2 loci: N G S T 1 1 G S T 1 2 G S T 1 0 G S T 2 1 G S T 2 2 Chinese 96 .1709 .0646 .7645 .8125 .1875 Indian 43 .1614 .2790 .5596 .7791 .2209 European 40 .1061 .0784 .8154 .8375 .1625 The GST 3 locus is expressed in erythrocytes and unlike the GST 1 and GST 2 loci is not polymorphic in the Australian Aboriginal, Australian Caucasian and Tokelau Island groups.
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