Abstract
Biochemical characterization of ratfish (Chimaera monstrosa) liver oil; cytotoxic and antineoplastic evaluation in cancer cell lines
Highlights
Shark liver oil (SLO), which is rich in alkylglycerols (AKGs), squalene, squalamine and other derivatives, has been widely used in Scandinavian countries as a complementary medicine for the treatment of a wide variety of diseases, cancer
Considerable numbers of fatty acids and AKGs were observed in the oil profile, which contribute to the antineoplastic and bioactivity of Ratfish liver oil (RLO)
The major portion of unsaturated fatty acids consisted of oleic acid (33.3%), gondoic acid (6.11%), linoleic acid (1.10%), eicosapentaenoic acid (EPA; 4.52%), and docosahexaenoic acid (DHA; 5.16%) (Table 1)
Summary
Shark liver oil (SLO), which is rich in alkylglycerols (AKGs), squalene, squalamine and other derivatives, has been widely used in Scandinavian countries as a complementary medicine for the treatment of a wide variety of diseases, cancer. RLO has a Keywords: ratfish liver oil, fatty acids, alkylglycerols, squalene, DMP1, DMTF1, cancer. Ratfish liver oil (RLO) with a high abundance of valuable fatty acids, alkylglycerols (AKGs) and their methoxy derivates, is an ancient traditional Scandinavian medicine used to enhance the immune response in immune-related diseases and cancer. Shark liver oil (SLO) or AKGs incorporated into pharmaceutical products have been shown to display several in vivo biological efficacies such as stimulation of the immune system and anti-tumor and anti-metastatic activities
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