Abstract
AbstractImmersion tests were performed with linear alkyl benzene sulfonate (LAS) for the evaluation of the consumer safety of household detergents. The test showed marked biochemical and pathomorphologic alterations in the skin of guinea pigs on exposure for 7 consecutive days for up to 90 min in 1% neutralized LAS solution. Increase in the activity of histidine decarboxylase and decrease in -SH, histamine, and lactic dehydrogenase along with hyperkeratinization and discontinuity in epidermis in the skin of the guinea pigs treated with LAS were found.
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