Abstract
Five new triterpenoids ( 1– 5), together with two known quassinoids, bruceantin ( 6) and bruceine A ( 7), and a known flavonolignan, (−)-hydnocarpin ( 8), were isolated from the chloroform-soluble subfraction of a methanol extract of the combined twigs, leaves, and inflorescence of Brucea javanica collected in Vietnam. The structures of the new compounds 1– 5 were established on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a small panel of human cancer cell lines. Quassinoids 6 and 7 were found to be highly active against these cell lines. (−)-Hydnocarpin ( 8) showed a potentiating effect when combined with both 6 and 7, during cytotoxicity testing using the MCF-7 human breast cancer cell line.
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