Abstract
Abstract The present study reports the dissolution studies of a family of boron-doped bioactive glasses based on the composition ICIE16. Simulated body fluid (SBF), Tris-buffered solution and lactic acid were used as dissolution media for studies under static and dynamic conditions. The leaching of ions from the glasses under the evaluated conditions and media was compared and the bioactive behaviour of the glasses was evaluated. Influence of the incorporation of boron in the thermal properties of the glass was also analysed. Glasses exhibited faster bioactivity under dynamic dissolution configuration compared to static conditions. Moreover, the glass dissolution rate was faster in acidic conditions than in SBF or Tris solutions. It was found that at increasing boron content the dissolution of the glass is faster.
Highlights
Bioactive glasses have been considered interesting materials for applications in bone and soft tissue engineering due to their characteristic of forming an interfacial bonding between the material and the body tissue [1, 2]
The present study reports the dissolution studies of a family of boron-doped bioactive glasses based on the composition ICIE16
Incorporation of therapeutic ions into bioactive glasses is of great interest due to the possibility to expand the properties of the material and promote additional beneficial effects, different biological active ions such as magnesium, zinc, strontium and boron have been studied as therapeutic agents in bone tissue engineering regarding the effect on osteoblast activity and angiogenesis [11, 12]
Summary
Bioactive glasses have been considered interesting materials for applications in bone and soft tissue engineering due to their characteristic of forming an interfacial bonding between the material and the body tissue [1, 2]. The biological effects of boron on the stimulation of wound healing, secretion of proangiogenic growth factors and upregulation of bone formation markers in vitro [13], make the incorporation of this ion into bioactive glasses interesting for potential applications in tissue engineering and regenerative medicine. Characterisation of the dissolution process of bioactive glasses in aqueous solutions is carried out in terms of changes that occur on the surface of the glass and in the solution These experiments are normally conducted under static conditions, which could lead to local ion saturation and increased pH values [18], dynamic dissolution configurations are a convenient alternative to analyse the leaching behaviour of the glasses under a continuous solution flow. This study aimed to increase the understanding of the dissolution behavior of ICIE16 silicatebased bioactive glasses under different conditions and to
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