Abstract
OBJECTIVES: To compare bioactive glass and autograft regarding their histomorphometric characteristics. METHODS: The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was filled with bioactive glass granules and the other, with autograft grafted from the contralateral side. The sides were randomized. Fourteen days after surgery, the animals were euthanized. RESULTS: Histologic analysis revealed that bone neoformation was equivalent among the two groups and the osteoblasts cell-count was higher in the femurs treated with bioactive glass. The osteocytes cell-count, however, was lower. The similarity in bone formation between both groups was consistent to literature findings. CONCLUSION: Bioactive glass is similar to autograft regarding bone neoformation in this animal model of cavitary bone defects. Level of Evidence III, Case-Control Study.
Highlights
Area of the quadrant femurs treated with bioactive glass have lower degrees of inflammatory infiltrate than those treated with autograft
We observed that femurs treated with bioactive glass, presented osteoblast counts greater than femurs treated with autograft, but the number of osteocytes was smaller
The main objective of this study was to compare the intensity of bone neoformation between the two groups, one treated with autograft and the other with bioactive glass granules
Summary
Bioactive glass in cavitary bone defects: a comparative experimental study in rabbits. The objective of this work was to compare histological characteristics of bone neoformation provided by bioactive glass in the repair of cavitary bone injuries and autograft, considered the gold standard. The number of osteoblasts, osteoclasts, and osteocytes was counted in the same microscope using the greater increase objective (Olympus - Plan CN 40x – area of 0.17mm2) in the area with the highest density of bone neoformation chosen by the pathologist.
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