Abstract
The interactions during wet granulation between microcrystalline cellulose and aqueous solutions of two molecular weight grades of two polymer binders, have been monitored using an instrumented mixer torque rheometer. The rheological behaviour indicated that different molecular weight grades of the same polymer exhibited different behaviour at equivalent viscosity. This observation could only partly be explained using traditionally considered theories relating binder surface tension to granule strength. An examination of polymer adsorption phenomena gave results consistent with earlier data indicating a different degree of interaction between the two polymer types, and possible preferential adsorption of high molecular weight molecules. A model to describe particle: binder behaviour during wet massing has been suggested to explain the observed differences in rheological behaviour.
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