Abstract
Uniform Nd3+-doped LuVO4 nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd3+ and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pH medium and high cell viability. Because of these properties, the developed Nd3+-doped LuVO4 nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography.
Highlights
Among the most interesting techniques for medical diagnosis are luminescent imaging (LI), magnetic resonance imaging (MRI), and X-ray computed tomography (CT) [1]
Several compounds have been assayed for such a purpose, among which rare earth vanadate (REVO4)-based nanophosphors composed by a REVO4 matrix in which different luminescent lanthanide (Ln) cations are introduced as dopants, have been recently the focus of much attention
We report on a procedure for the synthesis, for the first time in the literature, of uniform Nd3+-doped LuVO4 nanophosphors with nearly equiaxial shape by homogeneous precipitation at 120 ◦C from ethylene glycol (EG)/water solutions containing Ln3+ nitrates and sodium orthovanadate
Summary
Among the most interesting techniques for medical diagnosis are luminescent imaging (LI), magnetic resonance imaging (MRI), and X-ray computed tomography (CT) [1]. In both cases, the use of external probes as contrast agents is usually required. Ln-doped GdVO4 (Ln = Eu, Dy) nanoparticles have been shown to be promising candidates as both luminescent and MRI probes due to the magnetic properties of the Gd3+ cations [2,3,4,5]. This study demonstrates that the developed Nd3+:LuVO4 nanophosphors are promising candidates for their use as a bimodal probe for in vivo luminescent bioimaging and X-ray computed tomography
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
