Bibliometric analysis of papers on inflammation in glaucoma from 2000 to 2025.

This study aims to conduct a bibliometric analysis of global publications on the application of artificial intelligence (AI) in high myopia (HM). We retrieved publications on AI in HM from the Web of Science Core Collection (WoSCC) database, MEDLINE and Chinese Science Citation Database (CSCD) with data up to 2024. The analysis focused on publication and citation trends, identifying key articles, influential countries, institutions, authors, and journals. Additionally, we explored research domains and emerging keywords. A total of 167 relevant publications were included. The first AI-related paper on HM was published in 2017, with a significant surge in 2021, followed by a consistent increase in publication and citation counts over the next 3 years. China emerged as the most productive country, with the most extensive international collaboration. East Asian authors dominated the top 10 most influential authors. Yang, Weihua and Investigative Ophthalmology & Visual Science (IOVS) contributed the most publications among authors and institutions, respectively. Keyword analysis revealed that retinal imaging-related terms remained a consistent research focus, while newly emerging keywords included "automated detection" and "childhood." Recent advancements in AI applications for HM have been significant and are expected to continue. Future research will likely focus on multimodal imaging and improving algorithm accessibility. Our findings offered the first comprehensive overview of global research on AI in HM, thus providing valuable insights for researchers to understand the current status and future trends in this field.

Background: Glaucoma, a neurodegenerative disease of the retina, is the leading cause of irreversible blindness. Stem cells have therapeutic potential for glaucoma. However, few bibliometric studies have been published in this field. Concerning a visual map, this article aims to characterize the research context, cooperation relationship, hotspots, and trends concerning the application of stem cells in glaucoma research.Methods: Publications focusing on stem cell research and glaucoma were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, Microsoft Excel, and Scimago Graphica were used to map the contributions of countries or regions, authors, organizations, and journals. Journal Impact Factor data were obtained from the Web of Science Core Collection. We analyzed the tendencies, hotspots, and knowledge networks using VOSviewer, and CiteSpace.Results: We analyzed 518 articles published from 1999 through 2022. In the first decade, the number of articles in this field increased slowly, and there was a marked acceleration in publication frequency after 2010. The United States, China, and England were the main contributors. Yiqin Du was the most prolific author, and among the top 10 prolific writers, Keith R. Martin’s work was cited most frequently. Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Cornea published the most articles in this domain. The three most commonly co-cited journals were Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Proceedings of the National Academy of Sciences of the United States of America. The Central South University, the University of Pittsburgh, and the National Institutes of Health National Eye Institute were highly prolific institutions in this research area. Our keywords analysis with VOSviewer suggested directions of future research and yielded the following recent key themes, extracellular vesicles, exosomes, mitochondria, growth factors, oxidative stress, and ocular diseases. Four co-cited references had a citation burst duration until 2022.Conclusion: With improvements in overall quality of life and demographic transitions toward population aging, research and clinical focus on eye care has increased, with glaucoma as a key area of emphasis. This study added to our understanding of the global landscape and Frontier hotspots in this field.

The rapid spread of coronavirus disease 2019 (COVID-19) has attracted worldwide attention. There were also reported gastrointestinal symptoms in patients with COVID-19. This work aims to analyze the global research trends in COVID-19 and digestive disease. The related papers on COVID-19 and digestive disease were identified with Pubmed and web of science core collection on September 3, 2021. Bibliometric visualization was conducted through VOSviewer and CiteSpace. The analytic research was based on original articles and reviews. There were 997 articles found, with citations ranging from 0 to 878. These articles were distributed among 86 countries and 355 journals. The USA mainly contributed (288 articles), where 3 of the top 10 institutions were located. Followed by China (215 articles) and Italy (160 articles). The highest level of scientific collaboration has been formed between the USA to China. The World Journal of Gastroenterology (39 papers) published the most significant number of articles. Concerning the research topic, the colon/small bowel had the largest number of articles, followed by the liver and pancreaticobiliary. "Liver injury," "inflammatory bowel disease," "management," and "endoscopy" were the hotspot keywords. The largest cluster of liver transplantation had offered hints regarding research frontiers. The analytic results showed that the liver, especially liver transplantation, and inflammatory bowel disease were the 2 most influential research topics in COVID-19 and digestive disease.

Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020.

Microneedles can physically penetrate the stratum corneum, creating micropores on the skin, and allowing for drug delivery through direct diffusion, injection, or other methods. As a novel drug delivery method, it possesses significant application potential. This study uses bibliometric analysis to explore the research hotspots and development trends of microneedle-mediated drug delivery. Relevant research articles on microneedle-mediated drug delivery published between 1998 and 2024 in the Web of Science Core Collection (WoSCC) database were retrieved. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Pajek, enabling the prediction of research trends in microneedle-mediated drug delivery. In general, research on microneedle-mediated drug delivery has shown a continuous increase. China and the United States are the leading countries in this field of study. Notably, Ryan F. Donnelly (n=224) is the most prominent contributor to this field. The current core research directions include: disease treatment, enhancement of transdermal absorption performance of microneedles, vaccine delivery, and new materials and technologies for microneedle manufacturing. Microneedle-mediated drug delivery, as a novel technology and method, holds significant research value and application potential. However, further strengthening of international collaboration and the clinical translation of research findings are needed.

BackgroundThe exponential growth of artificial intelligence (AI) in healthcare has raised critical ethical concerns.AimsTo systematically identify research hotspots and trends of AI ethics in the medical field and provide evidence-based insights for future research.MethodsA bibliometric analysis was conducted on publications from the Web of Science Core Collection (WOSCC) and China National Knowledge Infrastructure (CNKI) up to August 24, 2025. Visualisation tools were used to map the publication trend, as well as author, country, institution, journal, and keyword distributions. Keyword co-occurrence networks, clustering and burst analysis were employed to identify research hotspots and evolving trends. The results are reported following the BIBLIO checklist.ResultsA total of 1034 publications (291 from CNKI, 743 from WOSCC) were included. Key journals were Chinese Medical Ethics (CNKI) and Journal of Medical Ethics (WOSCC). China (n = 291) and the USA (n = 174) were the top publishing countries in CNKI and WOSCC, respectively. Leading institutional output came from developed countries (e.g., Harvard University, University of London, University of Toronto). Four research hotspots were identified: 1) ethical issues in different application scenarios of AI techniques in clinical practice, 2) AI ethical concerns and considerations in medical academia, 3) ethical challenges in AI-driven medical education, and 4) ethical governance, supervision, and review in healthcare. Keyword burst analysis indicated an increasing attention on balancing AI development with ethical governance, promoting research on complex intelligent tools embedded with ethical principles.ConclusionAttention to this topic has grown steadily over the past eight years. Research trends reflect a shift from fragmentation to the integration of technology and ethics in medicine. Future research should further refine the operational definitions of ethical principles across diverse application scenarios to guide stakeholders in effectively integrating technology and ethics.

Neurovascular coupling (NVC) is the functional mechanism that links brain neural activity with the dynamic regulation of local blood flow and oxygenation. In recent years, there has been an increasing academic attention to the role of NVC in its pathophysiology and the application of new technologies. This study aims to map the research landscape related to NVC through scientometric analysis. Publications from the past 30 years were retrieved from the Web of Science Core Collection (WoSCC) database. Data were analyzed using CiteSpace, VOSviewer, and the bibliometrix R package, including co-citation and keyword co-occurrence network analyses. Key metrics such as publication counts and citation frequencies were assessed to identify trends and collaboration patterns among countries, institutions, and authors. Among the 2047 articles included in the study, United States has maintained a clear leading position. Meanwhile, the number of Chinese research participants has grown rapidly over the past decade. The most prolific authors were Professors Iadecola Costantino and Tarantini Stefano. The research findings of Professor Tarantini Stefano have been widely recognized by researchers in the field. Keyword analysis identified "cerebral blood flow," "neuronal activity," and "neurovascular coupling" as dominant terms, emphasizing the central role of brain function and imaging techniques such as fMRI, TCD, and optical imaging. The emergence of "fNIRS," "resting-state fMRI," and "autoregulation" highlights the growing impact of noninvasive neuroimaging in studying brain-blood flow interactions. Cluster analysis revealed key research themes including functional connectivity, nitric oxide-mediated vascular regulation, cerebral autoregulation, Alzheimer's disease metabolism, and CO2-induced hemodynamic modulation. Over the past three decades, NVC has emerged as a key research focus, driven by interdisciplinary collaboration and advances in brain connectivity, dysfunction, and technology. In the future, integrating artificial intelligence, multi-omics analysis, and high-resolution imaging will further elucidate NVC mechanisms in health and disease, promoting interdisciplinary translation and breakthroughs in neuroscience and brain health.

Aims: Three-dimensional (3D) printing of zirconia is an emerging domain in digital dentistry; however, its global research landscape, collaboration structure, and thematic focus have not been comprehensively mapped. The aim of this study was to characterize scientific output, collaboration patterns, citation impact, and major research themes in publications on 3D-printed zirconia in dentistry.Methods: A Web of Science Core Collection (WoS-CC) Topic Search was conducted in December 2025 using terms related to zirconia, additive manufacturing/3D printing, and dental applications. Of 584 retrieved records, 185 eligible articles on 3D-printed zirconia for dental use (2009–2025) were included. Descriptive indicators were calculated (annual production, journals, countries, institutions, authors, and citations). Co-authorship and keyword co-occurrence networks were generated with VOSviewer to visualize collaboration and identify thematic clusters.Results: Publication activity increased sharply after 2019, with 128/185 publications (69.2%) published in 2023–2025. Most documents were original research articles (n=159) or reviews (n=26); no case reports were identified in WoS-CC. The 185 articles involved 730 authors from 38 countries and were published in 48 journals. China and the United States were leading contributors. Network analyses identified three interconnected themes: digital/additive manufacturing workflows, implantprosthodontic applications, and biomechanical or accuracy-based evaluation. Evidence was predominantly in vitro and laboratory-based, with limited clinical data.Conclusion: Research on 3D-printed zirconia in dentistry is rapidly expanding but concentrated in a small set of countries, institutions, and journals. Future studies should prioritize clinical investigations and standardized reporting of printing and post-processing parameters to support translation into predictable outcomes.

The aim of this study is to make a bibliometric analysis of the articles on higher order thinking skills in the Web of Science Core Collection (WoSCC) database. Since the research topic has a universal dimension, it is considered important to describe the current situation as it will add a broader perspective to future studies on higher order thinking skills. Bibliometric analysis method was used to examine the articles on higher order thinking skills in the Web of Science Core Collection (WoSCC) database in terms of various variables. In this study, for bibliometric mapping analysis, the Web of Science Categories database was extensively searched on 17.09.2024, including the years 1970/2024 and under the subject headings "Metacognitive thinking skills" (Topic) or "Reflective thinking skills" (Topic) or "Creative thinking skills" (Topic) or "Critical thinking skills" in the search query. In the process of data analysis, descriptive characteristics of the studies on thinking skills were determined and the most effective journals on high-level thinking skills were identified. In addition, in the process of data analysis, the sources were categorized according to Bradford's law and the most cited articles worldwide were determined. On the other hand, the most influential authors on higher order thinking skills and the most frequently used keywords related to the subject together with the influential countries according to scientific production and citations were determined, and current research topics related to higher order thinking skills were identified.

Microperimetry is a novel technology to assess macular function. The aim of the study was to explore the global research status and trends in microperimetry. Documents related to microperimetry in ophthalmology from 1992 to 2022 were extracted from the Science Citation Index Expanded (SCI-E) database of the Web of Science Core Collection (WOSCC). Raw data were analyzed using the VOSviewer and CiteSpace software. Bibliometric parameters included annual publication quantity, countries, authors, journals, international cooperation, and keywords. A total of 1,217 peer-reviewed documents were retrieved. Annual research output has increased significantly since 2005, especially since 2013. Holz F, Rubin G, and Guymer R contributed most to the number of articles published about microperimetry. Rubin G, Fitzke F, and Holz F, respectively, received the most citations for their study. The countries publishing most were the USA, Italy, and the UK, while the USA, the UK, and Germany received the most citation frequency. Univ Bonn, UCL, and Moorfields Eye Hosp were the top three productive institutions for microperimetry research in the world. The top three journals that publish articles about microperimetry were Retina-The Journal of Retinal and Vitreous Diseases, Investigative Ophthalmology and Visual Science, and the American Journal of Ophthalmology. The top 10 common keywords included microperimetry, optical coherence tomography, eye, retinal sensitivity, macular degeneration, fundus autofluorescence, scanning laser ophthalmoscope, visual acuity, sensitivity, and degeneration. Keywords "optical coherence tomography angiography," "retinitis pigmentosa," and "internal limiting membrane" burst in the last 3 years. The bibliometric and knowledge graph analysis of research status and trends in microperimetry provided global researchers with valuable information to propose future cooperation and track cutting-edge progress.

To conduct a comprehensive bibliometric analysis of age-related macular degeneration (AMD) research from 2002 to 2022, identifying key contributing countries, institutions, authors, journals, and research hotspots to inform future research directions. Publications related to AMD were retrieved from the Web of Science Core Collection (WoSCC) database for the period January 1, 2002, to December 31, 2022. The search was limited to English-language articles and reviews. Bibliometric analysis was performed using Microsoft Excel 2021 for data management and annual publication analysis. Visualization and network analyses were conducted using VOSviewer, CiteSpace, and the Bibliometrix package in R. Collaboration networks among countries, institutions, authors, and journals were mapped. Keywords were analyzed for co-occurrence to identify research hotspots. Metrics such as H-index, total link strength (TLS), and citation counts were used to assess impact. A total of 16 715 publications were analyzed, showing a consistent increase in AMD research output over the past 20y, peaking at 1445 publications in 2021. The United States was the leading contributor with 31.8% of total publications, followed by China and the United Kingdom. The University of Melbourne emerged as the most productive institution with the highest TLS, indicating strong international collaborations. Professor Frank G. Holz was identified as the most influential author based on H-index and publication count. Investigative Ophthalmology & Visual Science was the most prolific journal and had the highest citation impact. Keyword co-occurrence analysis revealed four main research clusters: pathogenesis, therapy, epidemiology, and diagnosis. Emerging research hotspots included anti-vascular endothelial growth factor (VEGF) therapies, optical coherence tomography angiography, and artificial intelligence (AI) applications in diagnosis. The bibliometric analysis highlights significant growth and collaborative efforts in AMD research globally. Key contributors have advanced understanding in pathogenesis, therapeutic strategies, epidemiology, and diagnostic technologies. Future research should focus on interdisciplinary collaborations, novel therapeutic targets, personalized medicine, and technological innovations such as AI to effectively address the challenges posed by AMD.

BackgroundInflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide a comprehensive overview of the current status, hotspots and trends in DE anti-inflammatory research through bibliometric analysis.MethodAll publications were searched using the Web of Science Core Collection (WoSCC) database from 2004 to 2024. Bibliometric analyses were performed using VOSviewer, R-bibliometrix, and CiteSpace, and data were managed using Microsoft Office Excel 2019.ResultsThere were 603 papers published between 2004 and 2024 included in this study, with the number of papers increasing each year. The United States was the major contributor, with the largest number of publications and the greatest impact. Baylor College of Medicine was the most influential research institution. Pflugfelder, Stephen C. and Tsubota, Kazuo were the most prolific authors in this area of research, while Dana, Reza was the most cited author in the field with the highest impact. The Journal with the highest number of publications was Investigative Ophthalmology & Visual Science, while the highest impact journal was Ocular Surface. Research hotspots were focused on the mechanisms of inflammation in DE and interventions for anti-inflammatory therapy. Future studies would favor more inflammation-related targeted therapies and physical therapies.ConclusionThis study is the first bibliometric analysis to comprehensively summarize research trends and developments in DE anti-inflammatory treatments, pointing out recent research frontiers and hot directions for scholars studying DE anti-inflammatory treatments.

Purpose: To perform a bibliometric analysis in the field of amblyopia research to examine current global trends and future research hotspots and compare contributions from different countries, institutions, authors and journals. Methods: Literature related to amblyopia published from 1 January 2000, to 31 December 2024, was retrieved from the Web of Science Core Collection (WoSCC) database. The language of the included studies was limited to English, and the types of publications were articles and reviews. Visualization and bibliometric network analysis were performed using VOSviewer and CiteSpace. A cooperation network among countries, institutions, authors and journals was drawn. We conducted co-occurrence analysis on the keywords to identify the research hotspots. Results: A total of 4714 papers on amblyopia were identified from 2000 to 2024. In 2000, only 81 papers were published; however, by 2024, 292 papers had been published. Over the past 25 years, a total of 3618 universities or institutions in 94 countries or regions have published research papers related to amblyopia. The United States ranked first with 1607 papers, followed by China and England. McGill University published the most research papers on amblyopia, with 166 published papers, accounting for 3.5% of all publications on the subject. The top three journals contributing to this field were the Journal of Aapos, Investigative Ophthalmology & Visual Science and the Journal of Pediatric Ophthalmology & Strabismus. Binocular iPad games, ocular dominance plasticity and research on the visual cortex of the brain will become future research hotspots in this field. Conclusion: In this work, the publications were primarily from the United States and Europe.Plasticity of the visual cortex and the dominant eye has received attention from researchers in the field of amblyopia, and new technologies such as virtual reality technology have begun to be applied to treat amblyopia. This study reveals the hotspots and trends in this field through bibliometric analysis.

BackgroundHepatocellular carcinoma, a prevalent malignancy, threatens global health. Traditional Chinese medicine is widely applied in liver cancer treatment. This study assesses traditional Chinese medicine research trends and hotspots in this field through bibliometric analysis.MethodsPublications related to traditional Chinese medicine and liver cancer from 2011 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) database, and bibliometric analysis was conducted using VOSviewer, CiteSpace, and the R-bibliometrix.ResultsA total of 446 articles, led by China, were included, and the number of articles related to traditional Chinese medicine and liver cancer has been increasing year by year. Guangzhou University of Chinese Medicine and Shanghai University of Traditional Chinese Medicine are the main research institutions. Among the authors of these articles, Chen Yan has published the most papers, and JEMAL A has the most citations. Evidence-Based Complementary and Alternative Medicine is the most popular journals in this field and is also the most co-cited journal. Research focuses on integrating traditional Chinese medicine with modern medicine, with emerging hotspots including therapy, analysis systems, nanoparticles, and activation.ConclusionsThis first comprehensive bibliometric analysis clarifies research frontiers and guides future directions in liver cancer and Chinese herbal medicine studies.

ObjectiveThe present study seeks to extend previous bibliometric studies on eating disorders (EDs) by including a time-dependent analysis of the growth and evolution of multi-author collaborations and their correlation with ED publication trends from 1980 to 2014 (35 years).MethodsUsing standardized practices, we searched Web of Science (WoS) Core Collection (WoSCC) (indexes: Science Citation Index-Expanded [SCIE], & Social Science Citation Index [SSCI]) and Scopus (areas: Health Sciences, Life Sciences, & Social Sciences and Humanities) to identify a large sample of articles related to EDs. We then submitted our sample of articles to bibliometric and graph theory analyses to identify co-authorship and social network patterns.ResultsWe present a large number of detailed findings, including a clear pattern of scientific growth measured as number of publications per five-year period or quinquennium (Q), a tremendous increase in the number of authors attracted by the ED subject, and a very high and steady growth in collaborative work.ConclusionsWe inferred that the noted publication growth was likely driven by the noted increase in the number of new authors per Q. Social network analyses suggested that collaborations within ED follow patters of interaction that are similar to well established and recognized disciplines, as indicated by the presence of a “giant cluster”, high cluster density, and the replication of the “small world” phenomenon—the principle that we are all linked by short chains of acquaintances.