Bias in neuromodulation studies on chronic pain.

The challenges of academic physician-scientists in gastroenterology and hepatology: From managing indebtedness, securing grants, to managing conflicts

Mitigating Administrative Risks in Industry-sponsored Clinical Trials

Bias in clinical research originates when any systematic error is introduced into any phase of a study that may lead to untrue results. Bias can occur when the research question is formulated, and during data collection, analyses, interpretation, and/or reporting (including publication bias). Because study results distorted by bias might directly impact patient care and health-care policies, there have been great efforts by the scientific community to avoid the introduction of bias in cancer research. In this chapter we discuss the most frequent types of bias encountered in clinical oncology research, as well as potential solutions to minimize them.

Conflicts of interest, authorship, and disclosures in industry-related scientific publications: the tort bar and editorial oversight of medical journals.

From the ASGT president

Spinal Cord Stimulation and Evidence-Based Medicine—Cui Bono

More than a decade after the discovery of nociceptors, physicians still have very few options for treating chronic pain. Recent research on pain perception might finally be leading to new therapeutic strategies and drugs.

Chronic pain is a global health problem with a significant patient and socioeconomic burden. The technology of spinal cord stimulation (SCS), an efficient strategy for managing persistent pain, has undergone significant development in the previous couple of decades. The purpose of this paper is to review the development of SCS techniques, compare the efficacy of different SCS modalities, and explore future research directions. The article reviewed the development of SCS, including traditional tonic SCS, high-frequency SCS, burst SCS, and closed-loop SCS. Clinical trial and research data analysis were used to assess the safety and effectiveness of the different SCS modalities in the treatment of chronic pain. The study showed that high-frequency SCS and burst SCS were effective in relieving pain without producing paresthesia compared with conventional SCS. Closed-loop SCS provides a more personalized treatment plan by modulating stimulation through real-time feedback. However, the application of SCS still faces technical challenges, such as electrode displacement and equipment malfunction. SCS technology shows great potential in chronic pain management. With technological advances, SCS is expected to provide more effective and personalized treatment options for chronic pain patients. Subsequent investigations ought to concentrate on enhancing device stability, mitigating issues, and investigating astute and customized therapeutic alternatives.

SP61 Cost effectiveness of spinal cord stimulation in chronic low back pain

001 Cost effectiveness of spinal cord stimulation in chronic low back pain

Volume 100: clinical investigations: where next?

ESRA19-0475 Chronic pain neuromodulation for the anaesthesiologist not in practice, but why not in the future

There is much in the literature regarding the potential for commercial bias in clinical research and in continuing medical education (CME), but no studies were found regarding the potential for bias in reporting original research in CME venues. This pilot study investigated the presence of perceived bias in oral and print content of research findings presented in certified CME activities. Research presentations at two national primary care CME activities, where authors had self-reported potential conflicts of interest, were peer reviewed and monitored for perceived commercial bias. Blinded and unblinded peer reviewers' and monitors' analyses of bias were compared to assess whether knowledge of potential conflicts of interest affected perceptions of bias. Knowledge of potential conflicts of interest appeared to increase awareness of potential commercial bias with regard to use of a single product in care and assurance that there was reasonable evidence to support the practice recommendation. A perception of the presenter's strong opinion regarding care did not appear to be influenced by knowledge of a potential conflict of interest. While limited, by study design, this research detected subjectivity and variability in perceiving commercial bias within research findings presented in CME venues. Further study of these questions is required to guide the resolution of conflicts of interest in research and CME.

Issues in Long-term Opioid Therapy: Unmet Needs, Risks, and Solutions

Randomized controlled trials in CMI