Beyond the Surface: A Chronic Polypoid Mass Over the Lower Back That Finally Spoke!

Nevus Lipomatosus Superficialis With Dilated Hair Follicles

Nevus lipomatosus cutaneous superficialis (NLCS) is a relatively rare benign malformation characterized by ectopic deposition of mature adipose tissue in the collagen bundles of the dermis [[1] [2] [3] [4]]. NLCS is classified into two subtypes: the multiple (classical) type and solitary type [[1] [2] [3]]. The multiple type usually appears within the first two decades of life, most commonly in the pelvic girdle region and consists of flesh-colored or yellow papules or nodules [[3],[4]]. Also, its histopathological features are relatively uniform [[3]]. In contrast, the solitary type consists of a single nodular lesion without a favored location and it usually occurs in adults [[3]]. Surgical excision is a simple and adequate treatment for all lesions [[2]]. Recently, some authors have reported that CO2 laser is useful method of treatment for NLCS, especially in the multiple type [[4]].

Nevus lipomatosus cutaneous superficialis (NLCS) is a rare cutaneous hamartomatous lesion, histopathologically characterized by the presence of ectopic dermal adipocytes. Herein, reported is the clinicopathological aspect of six cases of NLCS, consisting of three males and three females, with age at presentation ranging from 18 to 47 years and duration of lesion ranging from 2 to 18 years. Out of the six cases, five were of solitary NLCS, who presented with nodules or polypoidal masses of variable sizes and duration. The lone case of classical NLCS presented with multiple skin-coloured cerebriform nodules over the right lower back in zosteriform distribution. The commonest location was lower back and thigh. Histopathological examination revealed lobules of mature adipocytes in the papillary and/or reticular dermis in all cases, thereby establishing the diagnosis of NLCS. Additional microscopic features encountered were surface ulceration, focal myxoid degeneration, mild perivascular lymphocytic infiltrate and attenuation of adnexal structures.

Nevus lipomatosus superficialis (NLS) is a rare benign condition characterized by papules and nodules usually in the pelvic and sacral areas, with ectopic mature adipose tissue reaching the superficial dermis. We report the case of a 47-year-old female with large NLS in the sacral region that had been present since birth and, after an asymptomatic course for most of the time, became associated with episodes of mild pain that prompted the patient to look for medical help. After a complete resection of the cerebriform plaque, measuring 23 cm in diameter, histopathological examination revealed typical NLS architecture in as yet undescribed association with multiple folliculosebaceous cystic hamartomas (FCHs) and dermoid cysts.

Nevus lipomatosus cutaneous superficialis (NLCS) is an uncommon lesion characterized by ectopic adipose tissue in the dermis and can be generalized or localized. It presents as a soft skin colored to yellowish papules or cerebriform plaques occurring usually on the buttock or thigh in a segment distribution. We report a case of NLCS in 38-year-old female, which was treated using the ultrapulse mode CO2 Laser. We describe the scientific logic and clinical results of using the ultrapulse mode in relation to the pathology of NLCS.

Nevus Lipomatosus Cutaneous Superficialis

Introduction: Nevus lipomatosus cutaneous superficialis (NLCS) is uncommon and can be encountered in various medical specialties. In this study, we report a rare case of solitary pedunculated nevus lipomatosus cutaneous superficialis in a middle-aged female patient and highlight its clinical and histopathological features. Case Presentation: A 43-year-old Malaysian female patient presented to our center with a 2-cm long and 1-cm wide solitary, flesh-colored nodule over the anterolateral aspect of her thigh. Excisional biopsy was performed, and the histopathology report showed NLCS. There are three types of NLCS, namely the solitary, multiple, and generalized forms. The etiology of NLCS is usually idiopathic, with no gender or familial preponderance. NLCS is usually misdiagnosed and should be differentiated from nevus sebaceous, connective tissue nevus, neurofibroma, lymphangioma, hemangioma, and focal dermal hypoplasia (also known as Goltz syndrome). Conclusions: In conclusion, NLCS is rare and benign condition, which should be differentiated from other malignant skin conditions as it is commonly misdiagnosed. Therefore, physicians and surgeons should be aware of its clinical and histopathological features.

A 45-year-old female presented with a history of pedunculated, soft, nodule on the right leg in popliteal region for 5 years. The lesion started as a small nodule and increased in size for 2 years and remained unchanged thereafter. The histological examination confirmed ectopic mature adipose tissue within dermis that supported the clinical diagnosis of nevus lipomatosus. This case report is of a solitary form of nevus lipomatosis cutaneous superficialis or pedunculated lipofibroma.

Congenital cutaneous solitary mixed hamartoma: An unusual case containing eccrine, neural, and lipomatous components

The literature review considers the role of ectopic adipose tissue in the formation of cardiometabolic risks. The aim of this publication is to systematize current data on the incidence and clinical characteristics of obesity associated with excessive accumulation of ectopic adipose tissue. Materials and methods . We carried out the search in PubMed electronic scientific databases and the database of the Russian scientific electronic library eLibrary for keywords and phrases: ectopic adipose tissue, perivascular adipose tissue, paranephral adipose tissue, epicardial adipose tissue, cardiovascular risk. Results . We carried out a comprehensive analysis of modern scientific data on the mechanisms of formation and the pathophysiological role of ectopic fat depots in the development of cardiovascular and metabolic diseases. We paid particular attention to various localizations of ectopic fat (epicardial, perivascular, visceral), their endocrine activity and the effect on metabolic processes. We considered mechanisms by which ectopic adipose tissue contributes to the development of insulin resistance, systemic inflammation, atherosclerosis and other pathological conditions. Conclusion . Excess ectopic adipose tissue deposits are a modifiable risk factor that should be considered as a therapeutic target for the development and application of novel targeted strategies in the diagnosis and treatment of obese patients.

Nevus lipomatosus cutaneous superficialis (NLCS) is an idiopathic hamartomatous condition characterized by the presence of mature adipose tissue in the dermis. We report a case of NLCS initially misdiagnosed as condyloma acuminata in a 14-year-old boy. This case highlights classic clinical and histologic features of NLCS. The case presented here underscores the need for a high degree of clinical suspicion in diagnosing NLCS and in differentiating benign anogenital lesions from sexually transmitted conditions to avoid unnecessary work-up and undue emotional stress.

Nevus lipomatosus cutaneous superficialis (NLCS) is a rare hamartoma of adipose tissue characterized by the ectopic build-up of adipose tissue among collagen bundles and proliferation of ectopic adipocytes in the dermis, which leads to an absence of connection to the subcutaneous tissue. Giant NLCS (over 15 × 15 cm) is even rarer. So far, the largest NLCS mass in the literature was a giant lesion measuring 50 × 50 cm on the sacral area reported in 2014. Herein, we report a case of an even larger NLCS lesion with a size of 106 × 30 cm on the back and sacral regions. These lesions had been left untreated and had grown from small yellowish papules and nodules to giant multilocular pedunculated masses with cerebriform surfaces over 24 years. To the best of our knowledge, the NLCS lesion presented here is the largest reported. The report aimed to increase clinicians’ awareness of this rare and easily misdiagnosed disease. Furthermore, physicians should be mindful that early recognition and appropriate treatment are essential for NLCS patients, and lesions of NLCS can coalesce into unimaginable huge masses if left untreated resulting in more significant therapeutic challenges.

Nevus lipomatosus cutaneous superficialis (NLCS) is a rare cutaneous hamartoma characterized by groups of mature fat cells in the dermis. The authors report a case of a dark-skinnned, 6-year-old, Brazilian girl with 1 lesion in the right upper chest, extending to the neck, since 1 year of age. The dermatological examination consisted of skin-colored and yellowish follicular papules, isolated and grouped into a papillomatous plaque. The biopsy revealed ectopic mature adipose tissue in the dermis, compatible with NLCS, perifollicular well-circumscribed fibroblast and collagen proliferation, and decreased elastic fibers in the papillary and upper reticular dermis. The finding of perifollicular fibrosis in NLCS is not common, having been first described in 2003. The perifollicular fibrosis is characteristic of other rare hamartoma, the perifollicular fibroma, but is also present in fibrofolliculomas or trichodiscomas, angiofibromas, and fibrotic papules on the face of tuberous sclerosis and postinflammatory fibrosis. This case is very similar to the first described case of NLCS with perifollicular fibrosis, and the authors believe that this is the second case of this entity, but they propose to name it NCLS with perifollicular fibromas, which better describes the nature of this lesion.

Nevus lipomatosus cutaneous superficialis (NLCS) is a rare hamartomatous condition characterized by ectopic mature adipose tissue. We are reporting a case of a 12-year-old female with soft, non-tender, pedunculated nodules with a cerebriform surface over her right lower back. The lesion fulfilled the criteria of the classic type of NLCS and was surgically removed with no visible recurrence on follow up.

Nevus lipomatosus superficialis (NLS) is a hamartoma of adipose tissue, rarely reported in the past 100 years. We treated one case, and we conducted a systematic review of the literature. A 41-year-old man presented with a cutaneous multinodular lesion in the posterior region near the right auricle. The lesion was excised and examined histopathologically. To review the literature, we searched PubMed with the keyword "NLS." The search was limited to articles written in English and whose full text was available. We analyzed the following data: year of report, nation of corresponding author, sex of patient, age at onset, duration of disease, location of lesion, type of lesion, associated symptoms, pathological findings, and treatment. Of 158 relevant articles in PubMed, 112 fulfilled our inclusion criteria; these referred to a total of 149 cases (cases with insufficient clinical information were excluded). In rare cases, the diagnosis of NLS was confirmed when the lesion coexisted with sebaceous trichofolliculoma and Demodex infestation. Clinical awareness for NLS has increased recently. NLS is an indolent and asymptomatic benign neoplasm that may exhibit malignant behavior in terms of huge lesion size and specific anatomical location. Early detection and curative treatment should be promoted.