Abstract
A 65 year old man presented with asymptomatic relapse of renal cell carcinoma with distant metastasis following radical nephrectomyfor pT3 pNx kidney cancer 7 years ago. Sunitinib was commenced with partial response as best response by the 9 month. Patient subsequently developed RECISTdefined radiographic progressive disease with associated clinical deterioration. Sunitinib was stopped and best supportive measures implemented. However, the patient’s metastatic lesions began to regress and is currently maintaining good functional status and has near complete radiographic response, approximately 40 months since cessation of sunitinib. Literature review revealed only two other cases of disease regression upon cessation of anti-angiogenic tyrosine kinase inhibitors. Potential mechanisms arediscussed as well.
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