Abstract
Dapagliflozin is a selective sodium-glucose cotransporter 2 nhibitor (SGLT2i) indicated for the treatment of type 2 diabetes mellitus (T2DM), heart failure with reduced ejection fraction and chronic kidney disease. In all indications, treatment can be initiated in adults with estimated glomerular filtration rate ≥25 ml/min/1,73 m². As monotherapy or as an additive therapy, dapagliflozin has been shown to promote better glycaemic control, associated with a reduction in body weight and blood pressure in a wide range of patients. In addition, dapagliflozin has a positive impact on arterial stiffness, helps to control the lipid profile and contributes to a reduced risk of cardiovascular complications. This article reviews the current scientific evidence on the role of dapagliflozin in cardiovascular risk factors including arterial stiffness, cardiovascular disease and heart failure in patients with T2DM, with the aim to help translating this evidence into clinical practice. The underuse of SGLT2i in actual clinical practice is also discussed. Key words: Dapagliflozin; Sodium-Glucose Transporter 2 Inhibitors; Type 2 Diabetes Mellitus; Cardiovascular Diseases; Heart Failure; Therapeutic Inertia.
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