Abstract
Bestrophins, named after their association with Best’s disease (vitelliform macular dystrophy) are transmembrane proteins that function as calcium‐activated chloride channels (CaCC's), but may also play a role in cell survival. Bestrophins exist in several isoforms. Bestrophin‐3 is a cyclic‐GMP‐regulated CaCC in vascular smooth muscle. Its role in the intestine has not been studied, but another isoform, bestrophin‐2, is present as a chloride or bicarbonate transporter in the goblet cells of the colon. We have here determined the expression of bestrophin‐3 in the intestine of C57BL/6 mice using immunohistochemistry and Western blotting.Bestrophin‐3 was detected in varying proportions in goblet cells all along the intestine, and also in glia‐like cells in the entire myenteric plexus, as well as in stromal cells mainly in the colon submucosa. Staining of cells in the myenteric plexus was also detected in P10 pups.Thus bestrophin‐3 is expressed in several specific locations along the intestine. Its function in these locales remains to be determined.
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