Abstract
The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and identified as palmariol B (1), 4-hydroxymellein (2), alternariol 9-methyl ether (3), and botrallin (4) by means of physicochemical and spectroscopic analysis. All the compounds were evaluated for their antibacterial, antifungal, antinematodal and acetylcholinesterase inhibitory activities. 4-Hydroxymellein (2) exhibited stronger antibacterial activity than the other compounds. Palmariol B (1) showed stronger antimicrobial, antinematodal and acetylcholinesterase inhibitory activities than alternariol 9-methyl ether (3) which indicated that the chlorine substitution at position 2 may contribute to its bioactivity. The results indicate the potential of this endophytic fungus as a source of bioactive benzopyranones.
Highlights
Endophytic fungi which inhabit normal tissues of host plants without causing apparent symptoms of pathogenesis are novel and rich sources of bioactive natural products which include alkaloids, amines, amides, steroids, terpenoids, isocoumarins, quinines, flavonoids, phenyl propanoids, lignans, phenols, aliphatics, etc. [1,2,3,4,5,6]
Taken together the results indicate the potential of the endophytic fungus Hyalodendriella sp
The results indicate that the benzopyranones from the endophyte Hyalodendriella sp
Summary
Endophytic fungi which inhabit normal tissues of host plants without causing apparent symptoms of pathogenesis are novel and rich sources of bioactive natural products which include alkaloids, amines, amides, steroids, terpenoids, isocoumarins, quinines, flavonoids, phenyl propanoids, lignans, phenols, aliphatics, etc. [1,2,3,4,5,6]. [1,2,3,4,5,6] Due to this extensive potential, the objective of this work was to investigate the bioactive metabolites from an endophytic fungus Hyalodendriella sp. Ponipodef isolated from the healthy stems of the ‘Neva’ hybrid of Populus deltoides Marsh × P. nigra L. One benzopyranone that showed antimicrobial activity was previously obtained from this source and identified as botrallin [7]. Three other benzopyranones were isolated for the first time from the endophytic fungus. Ponipodef, identified, and their bioactivities, including antibacterial, antifungal, acetylcholinesterase inhibitory, and antinematodal properties, evaluated in order to provide data supporting the development and utilization of Hyalodendriella sp.
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