Translate 
Abstract
Purpose This study examined a plant extract (PE) foundation’s safety, antioxidant and protective properties. To offer a scientific foundation for the viability of creating ‘skincare makeup’ and improve the comprehension of cosmetic compositions’ efficacy evaluations. Methods Cellular assays tested six different concentrations (up to 5%) of the PE for cell viability levels and reactive oxygen species (ROS) levels of human immortalised epidermal cells (HaCaTs). The identified non-cytotoxic concentration (0.5% PE) was then tested by gene assays. A commercial foundation containing 0.5% PE (PEF0.5) was tested for safety, skin protective effectiveness, and user satisfaction. Results Compared to the control groups, 0.5% PE had a significant inhibitory effect on the expression level of MMP-1 but promoted the expression of COL1A1, COL3A1, ELN, and AQP3. PEF0.5 significantly (p < 0.05) reduced wrinkles and transepidermal water loss (TEWL) while improving hydration, glossiness, and elasticity for 14 and 28 days. Interestingly, sebum was reduced by PEF0.5 at 28 days without any negative consequences for 28 days. No significant (p > 0.05) differences were detected in the foundation’s effectiveness and usability. Conclusion Applying PEF0.5 for 28 days may improve the skin barrier function, as indicated by skin TEWL, hydration, wrinkle, elasticity, and sebum content, without any adverse effects.
Published Version
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
