Abstract
The fruits of the plant Dennettia tripetala G.Baker (Annonaceae) are well known in many communities of some southern states of Nigeria and some West African countries. They are commonly eaten as spices. We investigated the acute toxicity and behavioural effects of the essential oils of these fruits in mice and the mechanism(s) involved in the mediation of the observed behavioural effects. The result obtained showed that LD50 value of the oils in mice is 470 mg/kg (i.p.). The oils at all the dose levels used suppressed the gross behaviours and significantly (p
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