Abstract
Since the initial description of mild cognitive impairment (MCI), we have learned about the high prevalence of MCI compared to that of the common dementias.1 In this issue of Neurology ®, Duff et al.2 reveal that nearly 40% of those who are genetically at risk for Huntington disease (HD) meet criteria for MCI, using accepted cutoff scores, with higher rates in individuals closer to HD diagnosis. This prevalence rate is comparable to what is found for MCI in other neurodegenerative disorders such as Parkinson disease (PD).3 In contradistinction to pre-AD MCI and paralleling frequent findings in other basal ganglia disorders, Duff et al.2 found that MCI in their pre-HD cohort was predominantly nonamnestic in type, with single-domain …
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