Abstract
Battling brain-eating amoeba: Enigmas surrounding immunity to Naegleria fowleri.
Highlights
Free-living amoebas (FLA) are remarkable single-cell engines, foraging their way through a range of environments
Might differences in the immune response partially explain why certain individuals develop primary amoebic meningoencephalitis (PAM)? Studies of human serum and mucosal antibody titers have found widespread evidence of anti-Naegleria immune responses resulting from subclinical N. fowleri exposure [7,8,9,10]
These immune responses may arise after a nonolfactory exposure or olfactory clearance of less pathogenic strains of N. fowleri
Summary
Free-living amoebas (FLA) are remarkable single-cell engines, foraging their way through a range of environments. Occasionally these amoebas find themselves within a human host, and an unusual and deadly opportunistic infection unfolds. The FLA Naegleri fowleri is the causative agent for an invasive and lethal form of meningoencephalitis known as primary amoebic meningoencephalitis (PAM). N. fowleri infection and PAM are not a nationally notifiable disease, there is evidence that the latitude of reported infections has broadened over the past 10 to 15 years [1]. When paired with potentially increased water recreation, a warming climate may facilitate a collision course of amoebic growth and human activity
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