iScience | VOL. 25
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Bacteroides ovatus colonization influences the abundance of intestinal short chain fatty acids and neurotransmitters.

Publication Date May 20, 2022

Abstract

Gut microbes can synthesize multiple neuro-active metabolites. We profiled neuro-active compounds produced by the gut commensal Bacteroides ovatus invitro and invivo by LC-MS/MS. We found that B.ovatus generates acetic acid, propionic acid, isobutyric acid, and isovaleric acid. Invitro, B.ovatus consumed tryptophan and glutamate and synthesized the neuro-active compounds glutamine and GABA. Consistent with our LC-MS/MS-based invitro data, we observed elevated levels of acetic acid, propionic acid, isobutyric acid, and isovaleric acid in the intestines of B.ovatus mono-associated mice compared with germ-free controls. B.ovatus mono-association also increased the concentrations of intestinal GABA and decreased the concentrations of tryptophan and glutamine compared with germ-free controls. Computational network analysis revealed unique links between SCFAs, neuro-active compounds, and colonization status. These results highlight connections between microbial colonization and intestinal neurotransmitter concentrations, suggesting that B.ovatus selectively influences the presence of intestinal neurotransmitters.

Concepts
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Intestinal Neurotransmitters
Intestinal Short Chain Fatty Acids
Germ-free Controls
Neuro-active Compounds
Isovaleric Acid
Isobutyric Acid
Propionic Acid
Bacteroides Ovatus
Invitro Data
Colonization Status

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