Bactericidal Efficacy of a Mixture of Cimofloxacin, Metronidazole, Minocycline and Rifampicin against Bacteria of Carious and Endodontic Lesions of Human Deciduous TeethIn Vitro

Abstract

The aim of this study was to clarify the antibacterial efficacy mixture of ciprofloxacin, metronidazole and minocycline, with and without the addition of rifampicin (100 μg each/ml). against oral bacteria of children. More than 10 1 bacteria occurred in samples taken from carious (32 cases) and endodontic (28 cases) lesions, and from periodontal pockets (seven cases). However, none were recovered in vitro in the prcsence of the mixture. The mixture was also effective against the bacteria or dental plaque formed on deciduous teeth (16 cases). When carious and endodontic lesions on split surfaces of freshly cxtracled teeth wcrc covered overnight with α-tricalcium phosphate (TCP) cement containing the mixed drugs (1 per cent each: seven cases) or immersed in a solution of the mixed drugs (200 μg each/mil: two cases). No bacteria were recovered from the lesions, indicating that the mixture sterilised the lesions in situ . Topical application of the mixture of the drugs to carious and endodontic lesions, dissolved in water or mixed into dental materials. may be useful in dental treatment for children. Keywords: Caries: Ciprofloxacin: Deciduous teeth: Metronidazole; Minocycline; Rifampicin.