Abstract
European Journal of ImmunologyVolume 48, Issue 11 Back Cover PictureFree Access Back cover story: Eur. J. Immunol. 11'18 First published: 06 November 2018 https://doi.org/10.1002/eji.201870139AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Our back cover features H&E staining of a section from a mouse eye with experimental autoimmune uveitis (EAU), induced by immunization with IRBP, a retinal-specific antigen. The image shows a portion of the retina, adjacent to the optic nerve head, with changes typical for EAU, namely, retinal folding, loss of photoreceptor cells and intense infiltration of inflammatory cells. The image is taken from Lyu et al. (pp. 1810–1816), where the authors show that treatment with the compound TMP778 inhibited the development of EAU. TMP778 is a specific inhibitor of RORγt, the transcription factor for IL-17, but unexpectedly, the treatment inhibited the production of both IL-17 and IFN-γ. Volume48, Issue11November 2018 RelatedInformation
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