B-type Natriuretic Peptide Secretion following Scuba Diving

Abstract

To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m(2)), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.