Abstract
B lymphocytes are part of the adaptive immune system and responsible for the humoral arm of it. While the main task during early development is the production of a broad repertoire of naïve B cells, during further differentiation in the periphery the main task changes to the selection of the best fitting immunoglobulin producing B cell and its long-term survival. The homeostasis of this system is fine-tuned and reveals an age dependent balance between the different B-cell populations. The physiologic development and homeostasis is often disturbed in patients with immunodeficiency or autoimmunity. In this presentation, I will discuss the normal homeostasis of B cells and its analysis by flow cytometry. I will present altered B cell homeostasis in examples of patients with genetically defined and non-defined immunodeficiencies and autoimmune disorders and discuss the research, diagnostic and clinical value of the information we can draw from these findings.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
