Abstract
Azoxystrobin is a globally used strobilurin fungicide, which contaminates waterbodies through surface run-off. Its bioaccumulation in aquatic animals via food chains can induce serious pathophysiological disturbances. Therefore, histopathological and neuronal effects of azoxystrobin have been assessed in the fish, Pethia conchonius in the laboratory condition. Azoxystrobin-treated fish showed slow movement, crowding at the bottom, loss of equilibrium, and excess mucus secretion at all concentrations (0.025mg/L, 0.0514 mg/L, and 0.103mg/L) at 48 hours of exposure compared to the control. A significant dose and time-dependent inhibition in acetylcholinesterase activity was observed (p<0.05). The highest acetylcholinesterase inhibition (45.45 ± 1.07) was noted for the highest concentration at 96 hours of exposure than the control groups (88.35 ± 0.71). In contrast to the control, different histopathological changes in gill tissues have been observed like, epithelial lifting, lamellar fusion, epithelial hyperplasia, and the curling of secondary lamellae in the azoxystrobin-exposed groups after 24 hours of treatment. The results of this study indicated that azoxystrobin is neurotoxic as well as damaging to gills.
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