Abstract
Azelaic (AZ) acid is a non antibiotic drug used for an acne treatment. The AZ dry emulsion power was prepared by mixing power of AZ with dry emulsion base. The 20% AZ cream was obtained by addition of water into powder mixture with a ratio of 1:1 by weight. The dry emulsion base consisted of virgin coconut oil with an emulsifier, hydroxyproplymethylcellulose (HPMC). The physical properties of each primary coconut oil emulsion (COE) were evaluated as percent creaming, theirs viscosity and particle sizes. The results were shown that the emulsion system of 7.5% HPMC provided the suitable formulas with oil droplet particle size 1.23 ± 8.15 micrometer and its viscosity of 30405.02 ± 480.58 cps. After drying process, the moisture content of coconut oil dry emulsion (CODE) was 2.94%. The yield percentage of dry powder was 58%. Moreover, the flowability of dry emulsion powder was appeared to be fair (with an angle of repose of 35.35). After dry emulsion powder mixing with 20 % AZ and water, the AZ cream was appeared to be stable for at least one week with no significantly different in pH and amount of AZ. Thus AZ dry emulsion preparation could be used an alternative recipe for acne treatment with good stability during one week after reconstitution.
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