Abstract

The speed of sound (SoS) correlates with tissue properties and has been studied as a promising index for early detection and monitoring of diseases. Although the estimation of average SoS based on the phase aberration correction is the simplest and provides reasonable results for homogeneous media, the estimation error for the inhomogeneous media has not been clarified yet. Therefore, in this study, the backscattered signals of two inhomogeneous media were collected by using a previously developed simulator and the errors of average SoS estimation were analyzed. These results suggested that the statistical properties of the SoS distribution were related to the reliability of the average SoS estimation. In addition, these results may provide important insights for future clinical use of average SoS.

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