Abstract
Fenproporex is used worldwide as a powerful anorectic drug. This study was designed to evaluate whether daily intake of fenproporex would lead to behavioral and/or reproductive toxicity in adult male mice. Fourty male mice were used, divided into 4 groups of 10 animals each. The control group received only water by gavage, whereas the experimental groups were treated daily with fenproporex in the doses of 7.5, 15 and 30 mg kg-1, for a period of 40 days. The results demonstrated that fenproporex did not alter the normal evolution of the animals’ body mass; it also showed that the use of the drug did not promote behavioral toxicity (open-field and forced-swimming tests) or reproductive toxicity (genotoxicity, changes in the morphology of spermatozoa and testicular histology). Thus, the present results indicate that fenproporex, in the evaluated dose and experimental conditions, does not present behavioral and reproductive toxic potential in mice
Highlights
Em muitas nações do mundo, o excesso de peso da população representa um problema de saúde pública
Há também relatos de uso de anfetamínicos como agentes de dopagem no esporte (Damasceno et al, 2003), ou mesmo para prolongar o estado de vigília em trabalhadores noturnos e estudantes (Chasin e Silva, 2003)
Ainda que haja poucos estudos realizados com machos, Matei e Carlini (1996), após tratar de machos e de fêmeas de ratos com femproporex por 60 dias (10 mg kg-1 i.p.), observaram que o aumento da atividade motora e do comportamento estereotipado ocorre com maior intensidade nas fêmeas
Summary
Foram utilizados camundongos (Mus musculus) machos e fêmeas adultos da linhagem Swiss, pesando aproximadamente 35 g, provenientes do Biotério Central do Centro de Ciências Biológicas da Universidade Estadual de Londrina. Os animais passaram por um período de aclimatação de sete dias no biotério setorial antes do início do tratamento e foram mantidos individualmente em gaiolas de polipropileno com a tampa de arame zincado, contendo raspas de madeira. Durante a execução deste trabalho, os animais foram mantidos em regime de luminosidade controlada, ciclo de 12 horas claro/escuro, a 22 ± 2oC, com água e ração à vontade
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