Abstract
Several studies have been made in recent years on bone marrow lymphoid cells.5 The work of Osmond and Everett (1) and of Schooley and Giger (2) indicated that relatively few lymphoid cells from blood enter the normal marrow parenchyma of mice and guinea pigs. Previous work from this laboratory on the normal dog indicated that small lymphoid cells in bone marrow consist of two populations, one hematogenous, the other endogenous (3). Definite evidence for transformation of the hematogenous lymphoid cells into hemopoietic precursors was not obtained during the first 48 hours after injection of H3-thymidine. The present work extends these observations to the sublethally irradiated dog, in which the proliferation of lymphoid cells might be altered and their transformation into hemopoietic precursors stimulated. These problems were approached, as in previous work on the normal dog (3), by serial autoradiography with clamping of the hind limbs during the plasma clearance time of H3-thymidine injected into an anterior vein.
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