Abstract
The distribution of [ 3H]prostaglandins in the ocular tissues of rabbits was studied using autoradiography. Also the effect of intravitreally-injected prostaglandin E 1 on the intraocular pressure and blood-aqueous barrier was investigated. To a greater extent [ 3H]prostaglandins were distributed in the iris-ciliary processes following administration either into the anterior chamber or into the vitreous body. In the ciliary processes, [ 3H]prostaglandins were found predominantly in the stroma. Intravitreally-injected [ 3H]prostaglandins were transported out of the vitreous body very rapidly and did not appear in the aqueous humour. The intraocular pressure and protein content of the aqueous but not of the vitreous humour were found to increase within 15–30 min of the intravitreal injection of prostaglandin E 1. The leakage of India ink in the ciliary stroma of prostaglandin-treated eyes was observed. It is suggested that the site of action of prostaglandins on the blood-aqueous barrier is the ciliary processes.
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