Abstract
The regional distribution of [ 3H]idazoxan and [ 3H]rauwolscine was studied autoradiographically in human brain. [ 3H]Idazoxan binds with high affinity to α 2 adrenoceptors as well as to non-adrenergic sites (NAIBS). [ 3H]Rauwolscine, besides binding to α 2 adrenoceptors, also binds to 5-HT 1A receptors. Both radioligands labelled the same population of α 2 adrenoceptors, defined as the epinephrine-displaceable binding component. The highest densities of α 2 adrenoceptors occur in the leptomeninges, cerebral cortex and claustrum; lower densities were visualised in the basal ganglia, thalamus, pons, substantia nigra, cerebellum and medulla oblongata; no α 2 adrenoceptors were detected in amygdala and nucleus ruber. NAIBS were present in all the examined brain areas, with the highest densities found in the basal ganglia and substantia nigra. The finding that certain brain regions, such as the amygdala, contained NAIBS but no detectable α 2 adrenoceptors, suggests that the binding sites are independent from each other. The regional distribution of 5-HT 1A receptors labelled by [ 3H]rauwolscine is in agreement with previous studies using [ 3H]8-OH-DPAT.
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