Automatic Diagnosis for Glaucoma Fusing Multi-Feature and Multi-Classifier

Abstract

Glaucoma is a chronic and irreversible eye disease leading to blindness, and early detection is particularly important for its diagnosis and treatment. To improve the performance of automatic glaucoma diagnosis, a method based on multi-feature and multi-classifier is proposed. Firstly, an average histogram is obtained for each channel and ophthalmic condition, and 6 features are extracted from the average histogram with the average count of pixels and their maximum intensity value. Secondly, the optimal features combination is screened for each classifier with 10-fold cross-validation. Finally, the three optimal classifiers and their optimal features combination are fused with the principle of democratic voting. With the 10-fold cross-validation algorithm, the fusion model was evaluated on Local and HRF dataset, that achieved accuracy of 91.8% and 93.3%, sensitivity of 86.9% and 86.7%, specificity of 96.7% and 100%, AUC of 0.953 and 0.978, time cost of 1.0 s and 3.9 s per image, respectively. Simulation results show that the proposed method is of high accuracy and generality. It can effectively classify the retinal fundus images and provide technical support for the clinical diagnosis of retinal diseases.