Abstract
We tested 400 colorectal carcinoma patients preoperatively for serum antibodies to tumor cell cytoplasm and membrane, and for blood lymphocyte cytotoxicity against autochthonous tumor cells and serum blocking. All the patients were followed up postoperatively for 3 months to 8 1/2 years (mean 35 months) and their recurrence-free periods and survival times were assessed. In the 345 patients treated by curative resection a significant favorable association was found between autoantibody to tumor cytoplasm and disease-free survival. In the 55 patients treated by palliative resection there was a correlation between blood lymphocyte cytotoxicity and survival.
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