Abstract
Two enzymes, thrombin and autoprothrombin C, are derived from purified prothrombin by autocatalytic activation in 25% sodium citrate solution. The thrombin but not the autoprothrombin C activity is destroyed by diisopropylfluorophosphate. Autoprothrombin C is a procoagulant, which catalyzes the conversion of prothrombin to thrombin in a prothrombin-activating mixture consisting of calcium ions, Ac-globulin, and crude cephalin. Depending upon the amount of p-toluenesulphonyl-l-arginine methyl ester added to the prothrombin-activation mixture the thrombin generation may be retarded or inhibited completely. The view is expressed that all prothrombin activations are fundamentally autocatalytic. The end products of prothrombin activation involved are autoprothrombin C and thrombin, while the intermediate products of prothrombin activation are the autoprothrombins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
