Abstract
Objective: To investigate effects of Moderate Intensity Continuous Training (MICT) on the histomorphometric parameters of Inferior Vena Cava (IVC), Superior Vena Cava (SVC) and Aorta in rats. Methodology: Twenty-four male healthy Sprague Dawley rats were randomly divided into two equal groups. Exercise group was assigned to Moderate intensity continuous training on treadmill for four weeks and control group remained sedantary. Morphometry was performed using Image J software. Luminal diameter, wall thickness and media thickness were measured. Results: The luminal diameter (p<0.0001), wall thickness (p=0.04) and media thickness (p=0.016) of the IVC in exercise group significantly increased. In SVC, luminal diameter (p=0.8) was insigificantly increased while wall thickness (p=0.0001) and media thickness (p= 0.009) increased significantly in exercise group. Luminal diameter (p=0.9), wall thickness (p=0.95) and media thickness (0.16) of aorta showed no statistically significant difference between two groups. Conclusion: Moderate intensity continuous training had profound effects on histology of IVC and SVC while no statistically significant changes were observed in aorta. MICT produced more prominent early morphological adaptations in central large veins as compared to aorta.
Published Version
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