Abstract
Several epidemiological studies suggest the association between hearing loss and Alzheimer's disease (AD); however, the pathophysiological relationship between hearing loss and dementia remains to be fully defined. The aim of this study was to evaluate in an animal model of AD (3xTg-AD mice) if and how hearing loss induced by noise exposure at an age of 2 months (when the AD phenotype is not manifest yet) can accelerate and/or worsen AD-associated cognitive impairment, affecting auditory and hippocampal functions.
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