Abstract
In the present study, the effect of defatted hydromethanolic extract of Padina tetrastromatica on carbohydrate metabolism and serum lipid profile were evaluated. Diabetes mellitus was induced in male Wistar rats by feeding high calorie/energy diet for two months followed by a single intraperitoneal injecttion of streptozotocin. Diabetic rats were administered with the extract intragastrically at doses of 150, 300, 450, and 600 mg/kg body weight daily for 45 days. Treatment with graded doses showed a dose dependent reduction in blood glucose and glycated hemoglobin levels. Treatment significantly increased the activity of hexokinase, glucose-6-phosphate dehydrogenase and glycogen content while there was significant reduction in the activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase. Serum lipid profile was also brought back to near normal levels in a dose dependent manner. The present study clearly indicates the antihyperglycemic and hypolipidemic effects of P. tetrastromatica at an optimum dose of 450 mg/kg body weight.
Highlights
Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Global Health, Google
Two months of high calorie/ energy diet (HCD) feeding resulted in the development of insulin resistance, which was confirmed by the Effect of P. tetrastromatica on fasting blood glucose (FBG), HbA1c and glycogen content
Similar alphabets in the same column indicate no significant difference between groups; @: mg glucose phosphorylated/min/mg protein; #, $: μmol of Pi liberated/hr/mg protein; *: U/mg protein levels of fasting blood glucose (FBG) and serum triglyceride levels
Summary
Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Global Health, Google. There were no statistically significant differences between the FBG and HbA1c levels of diabetic rats of the groups V and VI, which indicated that 450 mg/kg body weight is the optimum dose for obtaining good glycemic control. Treatment of diabetic rats with P. tetrastromatica extract significantly elevated the glycogen levels in respect to the diabetic control (Table I).
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