Atrial fibrillation increases the risk of new-onset myocardial infarction amongst working-age population: apropensity-matched study.

Abstract

The aim of this study was to investigate the association between atrial fibrillation (AF) and new-onset myocardial infarction (MI) among aworking-age population in an industrial city of North China. In total 77,670participants aged under 60years were selected for this cohort study. Participants were divided into anAF group (n = 121) and anon-AF group (n = 74,565) based on their medical histories. Thereafter, 121participants from the AF group were propensity-matched with 363participants from the non-AF group. All participants were followed up from June 2006 to December 2020; new-onset MI was regarded as the endpoint of this study. Multivariate Cox proportional hazards regression analysis models were designed to analyze the correlation between AF and new-onset MI. During the 14-year follow-up, eight cases of new-onset MI were documented in the AF group, while five cases were documented in the non-AF group. The cumulative incidence of new-onset MI in the AF group (7.40%) was markedly higher than in the non-AF group (1.41%; p < 0.001). Atrial fibrillation was associated with an increased risk of new-onset MI in both univariate analysis (hazard ratio: 5.202, 95% confidence interval [CI]: 1.700-15.913) and multivariable-adjusted analysis (hazard ratio: 5.335, 95% CI: 1.683-16.910). Atrial fibrillation increased the risk of new-onset MI amongst working-age individuals in an industrial city of North China.